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In vitro and ex vivo measurement of the biophysical properties of blood using microfluidic platforms and animal models

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Abstract

Haemorheologically impaired microcirculation, such as blood clotting or abnormal blood flow, causes interrupted blood flows in vascular networks. The biophysical properties of blood, including blood viscosity, blood viscoelasticity, haematocrit, red blood bell (RBC) aggregation, erythrocyte sedimentation rate and RBC deformability, have been used to monitor haematological diseases. In this review, we summarise several techniques for measuring haemorheological properties, such as blood viscosity, RBC deformability and RBC aggregation, using in vitro microfluidic platforms. Several methodologies for the measurement of haemorheological properties with the assistance of an extracorporeal rat bypass loop are also presented. We briefly discuss several emerging technologies for continuous, long-term, multiple measurements of haemorheological properties under in vitro or ex vivo conditions.

Graphical abstract: In vitro and ex vivo measurement of the biophysical properties of blood using microfluidic platforms and animal models

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Publication details

The article was received on 06 Feb 2018, accepted on 11 Apr 2018 and first published on 11 Apr 2018


Article type: Critical Review
DOI: 10.1039/C8AN00231B
Citation: Analyst, 2018, Advance Article
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    In vitro and ex vivo measurement of the biophysical properties of blood using microfluidic platforms and animal models

    Y. J. Kang and S. Lee, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN00231B

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