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Potential of mid-infrared spectroscopy as a non-invasive diagnostic test in urine for endometrial or ovarian cancer

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Abstract

The current lack of an accurate, cost-effective and non-invasive test that would allow for screening and diagnosis of gynaecological carcinomas, such as endometrial and ovarian cancer, signals the necessity for alternative approaches. The potential of spectroscopic techniques in disease investigation and diagnosis has been previously demonstrated. Here, we used attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy to analyse urine samples from women with endometrial (n = 10) and ovarian cancer (n = 10), as well as from healthy individuals (n = 10). After applying multivariate analysis and classification algorithms, biomarkers of disease were pointed out and high levels of accuracy were achieved for both endometrial (95% sensitivity, 100% specificity; accuracy: 95%) and ovarian cancer (100% sensitivity, 96.3% specificity; accuracy 100%). The efficacy of this approach, in combination with the non-invasive method for urine collection, suggest a potential diagnostic tool for endometrial and ovarian cancers.

Graphical abstract: Potential of mid-infrared spectroscopy as a non-invasive diagnostic test in urine for endometrial or ovarian cancer

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Publication details

The article was received on 05 Jan 2018, accepted on 28 May 2018 and first published on 04 Jun 2018


Article type: Paper
DOI: 10.1039/C8AN00027A
Citation: Analyst, 2018, Advance Article
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    Potential of mid-infrared spectroscopy as a non-invasive diagnostic test in urine for endometrial or ovarian cancer

    M. Paraskevaidi, C. L. M. Morais, K. M. G. Lima, K. M. Ashton, H. F. Stringfellow, P. L. Martin-Hirsch and F. L. Martin, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN00027A

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