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Issue 1, 2017
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A general [18F]AlF radiochemistry procedure on two automated synthesis platforms

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Abstract

The aluminium fluoride-18 ([18F]AlF) radiolabelling procedure has generated great interest because it is a simple, one-pot method that can be used to directly radiolabel small molecules, peptides and proteins without the requirement for a [18F]fluoride drying step. Reported here is the development of an automated [18F]AlF radiolabelling procedure of three different precursors (one small molecule and two peptides) on two automated synthesis platforms: GE TRACERlab FXFN and Trasis AllInOne (AIO). Aiming at the clinical translatability of a [18F]AlF radiosynthetic methodology, the use of both platforms yielded radioconjugates with >98% radiochemical purity (RCP) within 26–35 min and required a single rapid purification step. The Trasis AIO platform gave improved [18F]fluoride incorporation, and generally produced radioconjugates with a higher radiochemical yield (RCY) and effective specific activities (SA) when compared to the GE TRACERlab FXFN system.

Graphical abstract: A general [18F]AlF radiochemistry procedure on two automated synthesis platforms

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Publication details

The article was received on 09 Nov 2016, accepted on 16 Jan 2017 and first published on 16 Jan 2017


Article type: Paper
DOI: 10.1039/C6RE00204H
Citation: React. Chem. Eng., 2017,2, 68-74
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    A general [18F]AlF radiochemistry procedure on two automated synthesis platforms

    L. Allott, C. Da Pieve, D. R. Turton and G. Smith, React. Chem. Eng., 2017, 2, 68
    DOI: 10.1039/C6RE00204H

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