Issue 3, 2017

Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas

Abstract

A flow chemistry process for the synthesis of 2-substituted cyclobutanones, via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas, is reported. Our approach uses rapid and mild reaction conditions to access a diverse array of products with good to excellent yield, alongside a good level of functional group compatibility.

Graphical abstract: Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas

Supplementary files

Article information

Article type
Communication
Submitted
13 Feb 2017
Accepted
06 Mar 2017
First published
06 Mar 2017
This article is Open Access
Creative Commons BY license

React. Chem. Eng., 2017,2, 295-298

Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas

C. Battilocchio, G. Iannucci, S. Wang, E. Godineau, A. Kolleth, A. De Mesmaeker and S. V. Ley, React. Chem. Eng., 2017, 2, 295 DOI: 10.1039/C7RE00020K

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