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Issue 1, 2017
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Halogenation of organic compounds using continuous flow and microreactor technology

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Abstract

The halogenation of organic substrates is one the most important transformations in organic synthesis. The most straightforward, inexpensive and atom economic halogenations involve the use of elemental halogens (X2) or hydrogen halides (HX). However, X2 and HX reagents are highly reactive, toxic and corrosive materials. Halogenations using these reagents are usually very fast and exothermic reactions, in which selectivity issues occur. Using continuous flow chemistry halogenations involving X2 and HX can be performed in a safe and controllable manner. Reagents can be accurately dosed even for gas/liquid reactions, and exotherms are easily controlled. Hazardous chemicals can be readily quenched in line avoiding any undesired exposures and significantly enhancing the process safety.

Graphical abstract: Halogenation of organic compounds using continuous flow and microreactor technology

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Publication details

The article was received on 08 Oct 2016, accepted on 09 Nov 2016 and first published on 16 Nov 2016


Article type: Review Article
DOI: 10.1039/C6RE00186F
Citation: React. Chem. Eng., 2017,2, 7-19
  • Open access: Creative Commons BY license
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    Halogenation of organic compounds using continuous flow and microreactor technology

    D. Cantillo and C. O. Kappe, React. Chem. Eng., 2017, 2, 7
    DOI: 10.1039/C6RE00186F

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