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Issue 83, 2017, Issue in Progress
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Development of noncytotoxic silver–chitosan nanocomposites for efficient control of biofilm forming microbes

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Abstract

Severe bacterial and fungal infections have become a major clinical and public health concern. Nowadays, additional efforts are needed to develop effective antimicrobial materials that are not harmful to human cells. This work describes the synthesis and characterization of chitosan–ascorbic acid–silver nanocomposites as films exhibiting high antimicrobial activity and non-cytotoxicity towards human cells. The reductive and stabilizing activity of both the biocompatible polymer chitosan and ascorbic acid were used in the synthesis of silver nanoparticles (AgNPs). Herein, we propose an improved composite synthesis based on medium average molecular weight chitosan with a high deacetylation degree, that together with ascorbic acid gave films with a uniform distribution of small AgNPs (<10 nm) exhibiting high antimicrobial activity against biofilm forming bacterial and fungal strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. At the same time, the resulting solid nanocomposites showed, at the same doses, reduced or totally excluded cytotoxicity on mammalian somatic and tumoral cells. Data obtained in the present study suggest that adequately designed chitosan–silver nanocomposites are powerful and promising materials for reducing pathogenic microorganism-associated infections without harmful effects towards mammalian cells.

Graphical abstract: Development of noncytotoxic silver–chitosan nanocomposites for efficient control of biofilm forming microbes

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Publication details

The article was received on 28 Jul 2017, accepted on 02 Nov 2017 and first published on 13 Nov 2017


Article type: Paper
DOI: 10.1039/C7RA08359A
Citation: RSC Adv., 2017,7, 52398-52413
  • Open access: Creative Commons BY license
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    Development of noncytotoxic silver–chitosan nanocomposites for efficient control of biofilm forming microbes

    A. Regiel-Futyra, M. Kus-Liśkiewicz, V. Sebastian, S. Irusta, M. Arruebo, A. Kyzioł and G. Stochel, RSC Adv., 2017, 7, 52398
    DOI: 10.1039/C7RA08359A

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