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Issue 61, 2017, Issue in Progress
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Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T2 contrast agents for high-field MRI

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Abstract

Poly(ethylene glycol) (PEG)-coated transition metal ferrite (MFe2O4; M = Co, Cu, Fe, Mn, Ni, Zn) nanoparticles (NPs) were generated by a one-pot synthetic protocol and found to be small, fairly monodisperse, and superparamagnetic in nature. When evaluated for high-field magnetic resonance imaging, these showed high values of r2 and r2/r1 at 9.4 T. The well-documented biocompatibility of PEG coatings makes these NPs attractive candidates as T2 contrast agents for high-field MRI. A systematic comparison of magnetic and relaxivity measurements reveals MnFe2O4 and CoFe2O4 NPs to be superior T2 MRI contrast agents compared to Fe3O4 NPs.

Graphical abstract: Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T2 contrast agents for high-field MRI

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Publication details

The article was received on 15 May 2017, accepted on 15 Jul 2017 and first published on 02 Aug 2017


Article type: Paper
DOI: 10.1039/C7RA05495E
Citation: RSC Adv., 2017,7, 38125-38134
  • Open access: Creative Commons BY-NC license
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    Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T2 contrast agents for high-field MRI

    A. Banerjee, B. Blasiak, E. Pasquier, B. Tomanek and S. Trudel, RSC Adv., 2017, 7, 38125
    DOI: 10.1039/C7RA05495E

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