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Issue 17, 2017, Issue in Progress
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Conformational stabilization of isatin Schiff bases – biologically active chemical probes

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Abstract

Isatin Schiff base derivatives have a wide range of biological effects. Unfortunately, these compounds possess a serious topological shortcoming: the conformational EZ interconversion. Two ways of conformation stabilization are reported here: complexation with metals that stabilize the E-conformer and substitution in the 4th position of the isatin core stabilizing the Z-form.

Graphical abstract: Conformational stabilization of isatin Schiff bases – biologically active chemical probes

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Publication details

The article was received on 14 Nov 2016, accepted on 27 Jan 2017 and first published on 06 Feb 2017


Article type: Paper
DOI: 10.1039/C6RA26779C
Citation: RSC Adv., 2017,7, 10070-10073
  • Open access: Creative Commons BY-NC license
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    Conformational stabilization of isatin Schiff bases – biologically active chemical probes

    A. S. Smirnov, D. N. Nikolaev, V. V. Gurzhiy, S. N. Smirnov, V. S. Suslonov, A. V. Garabadzhiu and P. B. Davidovich, RSC Adv., 2017, 7, 10070
    DOI: 10.1039/C6RA26779C

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