Issue 6, 2017

Solvent-free synthesis of polyhydroquinoline derivatives employing mesoporous vanadium ion doped titania nanoparticles as a robust heterogeneous catalyst via the Hantzsch reaction

Abstract

Mesoporous vanadium ion doped titania nanoparticles (V–TiO2) were used as a reusable and robust heterogeneous catalyst for one-pot four component synthesis of polyhydroquinoline derivatives via the esteemed Hantzsch reaction using arylaldehyde, β-ketoester, dimedone and ammonium acetate at 80 °C under solvent-free conditions as a multi-component synthesis. On the other hand, the catalytic activity of V–TiO2 was compared with undoped commercial titania nanocatalyst. This protocol was successfully pertinent to a wide range of structurally diverse arylaldehydes with β-ketoester, dimedone and ammonium acetate to afford the corresponding polyhydroquinoline derivatives. Operational simplicity, short reaction time and satisfactory yields are the key features of this protocol. The catalyst could easily be recycled and reused without observable decrease in catalytic activity.

Graphical abstract: Solvent-free synthesis of polyhydroquinoline derivatives employing mesoporous vanadium ion doped titania nanoparticles as a robust heterogeneous catalyst via the Hantzsch reaction

Supplementary files

Article information

Article type
Paper
Submitted
11 Nov 2016
Accepted
05 Dec 2016
First published
13 Jan 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 3611-3616

Solvent-free synthesis of polyhydroquinoline derivatives employing mesoporous vanadium ion doped titania nanoparticles as a robust heterogeneous catalyst via the Hantzsch reaction

G. B. Dharma Rao, S. Nagakalyan and G. K. Prasad, RSC Adv., 2017, 7, 3611 DOI: 10.1039/C6RA26664A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements