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Issue 11, 2017, Issue in Progress
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Synthesis of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin

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Abstract

A series of novel enantiomerically pure spiro-isoxazolidines and spiro-isoxazolines were synthesized regioselectively by 1,3-dipolar cycloaddition using respectively two dipoles, nitrones and nitrile oxides, on the exocyclic double bond of the B ring of tomentosin (α-methylene-γ-butyrolactone), a sesquiterpene lactone extracted from Dittrichia viscosa.

Graphical abstract: Synthesis of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin

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Publication details

The article was received on 26 Oct 2016, accepted on 05 Jan 2017 and first published on 19 Jan 2017


Article type: Paper
DOI: 10.1039/C6RA25869G
Citation: RSC Adv., 2017,7, 6523-6529
  • Open access: Creative Commons BY license
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    Synthesis of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin

    M. Zaki, A. Oukhrib, M. Akssira and S. Berteina-Raboin, RSC Adv., 2017, 7, 6523
    DOI: 10.1039/C6RA25869G

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