Issue 11, 2017, Issue in Progress

Synthesis of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin

Abstract

A series of novel enantiomerically pure spiro-isoxazolidines and spiro-isoxazolines were synthesized regioselectively by 1,3-dipolar cycloaddition using respectively two dipoles, nitrones and nitrile oxides, on the exocyclic double bond of the B ring of tomentosin (α-methylene-γ-butyrolactone), a sesquiterpene lactone extracted from Dittrichia viscosa.

Graphical abstract: Synthesis of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin

Supplementary files

Article information

Article type
Paper
Submitted
26 Oct 2016
Accepted
05 Jan 2017
First published
19 Jan 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 6523-6529

Synthesis of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin

M. Zaki, A. Oukhrib, M. Akssira and S. Berteina-Raboin, RSC Adv., 2017, 7, 6523 DOI: 10.1039/C6RA25869G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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