Issue 46, 2017

Synthesis and bioconjugation of first alkynylated poly(dithieno[3,2-b:2′,3′-d]pyrrole)s

Abstract

First synthesis of an alkynylated dithieno[3,2-b:2′,3′-d]pyrrole (DTP) monomer was developed, which allows electrochemical polymerization on platinum and indium tin oxide (ITO) electrodes. The obtained DTP-based polymer (pDTP) was successfully post-modified with redox active and biological entities via bio-orthogonal 1,3-dipolar cycloaddition reactions and [2 + 2]-cycloaddition. In vitro experiments with A549-human lung carcinoma cells evidenced the general biocompatibility of the compositionally tuneable pDTP-coated electrodes.

Graphical abstract: Synthesis and bioconjugation of first alkynylated poly(dithieno[3,2-b:2′,3′-d]pyrrole)s

Supplementary files

Article information

Article type
Communication
Submitted
06 Sep 2017
Accepted
05 Nov 2017
First published
06 Nov 2017

Polym. Chem., 2017,8, 7113-7118

Synthesis and bioconjugation of first alkynylated poly(dithieno[3,2-b:2′,3′-d]pyrrole)s

S. Schmid, J. Gačanin, Y. Wu, T. Weil and P. Bäuerle, Polym. Chem., 2017, 8, 7113 DOI: 10.1039/C7PY01528C

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