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Issue 36, 2017
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Versatile multicompartment nanoparticles constructed with two thermo-responsive, pH-responsive and hydrolytic diblock copolymers

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Abstract

Multicompartment block copolymer nanoparticles (MCBNs) constructed with a thermo-responsive and base-sensitive poly(N-acryloylsarcosine methyl ester)-block-polystyrene (PNASME-b-PS) and a pH-responsive poly(4-vinylpyridine)-block-polystyrene (P4VP-b-PS) are synthesized by dispersion RAFT polymerization employing two macro-RAFT agents. These MCBNs contain a hydrophobic polystyrene (PS) core and dispersed microdomains formed either by the pH-responsive poly(4-vinylpyridine) (P4VP) and/or the thermo-responsive and base-sensitive poly(N-acryloylsarcosine methyl ester) (PNASME). By changing the polymerization degree of the PS block, the molar ratio of two diblock copolymers, temperature, pH, and tuning the interaction between the acidic poly(N-acryloylsarcosine) block obtained from hydrolysis of PNASME and the alkaline P4VP block, convenient tuning of the size and morphology of the MCBNs is achieved, and well-defined block copolymer nanoparticles including several MCBNs with different microdomains, core–corona particles and shell-bonded core–shell nanoparticles have been prepared.

Graphical abstract: Versatile multicompartment nanoparticles constructed with two thermo-responsive, pH-responsive and hydrolytic diblock copolymers

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Publication details

The article was received on 17 Jul 2017, accepted on 14 Aug 2017 and first published on 14 Aug 2017


Article type: Paper
DOI: 10.1039/C7PY01182B
Citation: Polym. Chem., 2017,8, 5593-5602
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    Versatile multicompartment nanoparticles constructed with two thermo-responsive, pH-responsive and hydrolytic diblock copolymers

    S. Chen, X. Chang, P. Sun and W. Zhang, Polym. Chem., 2017, 8, 5593
    DOI: 10.1039/C7PY01182B

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