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Synthesis of amphiphilic fluorescent polymers via one-pot combination of multicomponent Hantzsch reaction and RAFT polymerization and their cell imaging applications

Abstract

Recently, the amphiphilic fluorescent polymers based on aggregation-induced emission (AIE) are attracting numerous attentions for their application in bioimaging field. In this study, employing PEGMA and TPB as hydrophilic and hydrophobic segments, novel amphiphilic polymers with AIE feature were successfully prepared via the combination of RAFT polymerization and Hantzsch reaction for the first time. For the same 25% feed ratio of TPB, the molar fraction of TPB in two-step PEG-DHP1 polymers and one-pot PEG-DHP2 polymers was respectively about 20.2% and 23.5%, and their weight average molecular (Mn) was about 21000 and 25000 with narrow PDI. From the 1H NMR analysis, the polymers structure by one-pot method was similar to that by two-step method. When the feed ratio increased to 30%, the molar fraction of TPB in one-pot PEG-DHP3 polymers and the corresponding Mn respectively changed to 27.6% and 20000. In aqueous solution, the obtained amphiphilic PEG-DHP2 polymers tended to self-assemble into fluorescent organic nanoparticles (FONs) with 100-200 nm size, whose fluorescence spectrum presented the maximal emission peak at 460 nm with the obvious AIE phenomenon. More importantly, as the result of the high water dispersibility, good fluorescence, nano morphology and excellent biocompatibility, the as-prepared polymers were attractive for the application in cell imaging.

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Publication details

The article was received on 04 Jun 2017, accepted on 12 Jul 2017 and first published on 17 Jul 2017


Article type: Paper
DOI: 10.1039/C7PY00926G
Citation: Polym. Chem., 2017, Accepted Manuscript
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    Synthesis of amphiphilic fluorescent polymers via one-pot combination of multicomponent Hantzsch reaction and RAFT polymerization and their cell imaging applications

    Z. Huang, Q. Chen, Q. Wan, K. Wang, J. Yuan, X. Zhang, L. Tao and Y. Wei, Polym. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7PY00926G

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