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Issue 7, 2017
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Vesicles of double hydrophilic pullulan and poly(acrylamide) block copolymers: a combination of synthetic- and bio-derived blocks

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Abstract

The formation of vesicular structures with average diameters from 200 to 300 nm consisting of double hydrophilic diblock copolymers pullulan-b-poly(N,N-dimethylacrylamide) (Pull-b-PDMA) and pullulan-b-poly(N-ethylacrylamide) (Pull-b-PEA) in aqueous solution is described. Bio-derived pullulan was depolymerized and functionalized with alkyne endgroups. Furthermore, azide end functionalized acrylamide blocks PDMA and PEA were synthesized via RAFT polymerization. Individual blocks were conjugated via copper catalyzed azide alkyne cycloaddition (CuAAC) to afford defined double hydrophilic block copolymers. Aqueous solutions of the synthesized block copolymers showed formation of completely hydrophilic vesicles that were observed via various techniques including dynamic light scattering (DLS), static light scattering (SLS), laser scanning confocal microscopy (LSCM), and cryogenic scanning electron microscopy (SEM).

Graphical abstract: Vesicles of double hydrophilic pullulan and poly(acrylamide) block copolymers: a combination of synthetic- and bio-derived blocks

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Publication details

The article was received on 22 Dec 2016, accepted on 09 Jan 2017 and first published on 09 Jan 2017


Article type: Paper
DOI: 10.1039/C6PY02212J
Citation: Polym. Chem., 2017,8, 1244-1254
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    Vesicles of double hydrophilic pullulan and poly(acrylamide) block copolymers: a combination of synthetic- and bio-derived blocks

    J. Willersinn, A. Bogomolova, M. B. Cabré and B. V. K. J. Schmidt, Polym. Chem., 2017, 8, 1244
    DOI: 10.1039/C6PY02212J

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