Jump to main content
Jump to site search

Issue 8, 2017
Previous Article Next Article

Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

Author affiliations

Abstract

Star-shaped poly(ethylene glycol)-N-hydroxysuccinimide (star-PEG-NHS) has shown great promise in a variety of biomedical applications owing to its non-toxicity, innate non-immunogenic properties and versatile, multifunctional end groups. However, its complex and sophisticated synthetic methods, as well as high costs, have significantly impeded its wide application. Here, we report the design and synthesis of a hyperbranched PEG-based polymer with multiple NHS functional groups (>12). The hyperbranched PEG-based multi-NHS polymer can react easily with a protein (bovine serum albumin, BSA) to form a PEG-protein hydrogel that displays great potential for biomedical applications.

Graphical abstract: Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Oct 2016, accepted on 22 Dec 2016 and first published on 04 Jan 2017


Article type: Communication
DOI: 10.1039/C6PY01719C
Citation: Polym. Chem., 2017,8, 1283-1287
  •   Request permissions

    Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

    S. A, Q. Xu, D. Zhou, Y. Gao, J. M. Vasquez, U. Greiser, W. Wang, W. Liu and W. Wang, Polym. Chem., 2017, 8, 1283
    DOI: 10.1039/C6PY01719C

Search articles by author

Spotlight

Advertisements