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Issue 9, 2017
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A triple action chemosensor for Cu2+ by chromogenic, Cr3+ by fluorogenic and CN by relay recognition methods with bio-imaging of HeLa cells

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Abstract

A triple action chemosensor (R1) bearing a rhodamine and thiophene moiety was synthesized by a simple condensation reaction. The sensing behaviour and selectivity of the synthesized chemosensor toward metal ions were studied by UV-Vis and fluorescence spectroscopy. The chemosensor recognized Cu2+ and Cr3+ ions with significant changes in UV-Vis absorbance and fluorescence intensity. The results showed that Cr3+ induced greater fluorescence enhancement whereas Cu2+ ions bound strongly with the receptor by showing a strong absorption band at 554 nm but with weak fluorescence. A visible colour change was observed by the addition of Cu2+ and that colour change is due to the opening of the spirolactam ring triggered by the addition of Cu2+ ions. Job's plot analysis indicated a 1 : 2 and 1 : 1 binding stoichiometry between the chemosensor and Cr3+/Cu2+. Subsequently, the R1 − Cu2+ complex chemosensor was employed to detect CN in the presence of different anions, such as F, Cl, Br, I, AcO, H2PO4, HSO4, NO3 and OH. In addition, the live cell imaging of HeLa cells using R1 and Cr3+ was demonstrated successfully.

Graphical abstract: A triple action chemosensor for Cu2+ by chromogenic, Cr3+ by fluorogenic and CN− by relay recognition methods with bio-imaging of HeLa cells

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Publication details

The article was received on 04 May 2017, accepted on 18 Jul 2017 and first published on 19 Jul 2017


Article type: Paper
DOI: 10.1039/C7PP00163K
Citation: Photochem. Photobiol. Sci., 2017,16, 1441-1448
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    A triple action chemosensor for Cu2+ by chromogenic, Cr3+ by fluorogenic and CN by relay recognition methods with bio-imaging of HeLa cells

    N. Vijay, G. Balamurugan, P. Venkatesan, S. P. Wu and S. Velmathi, Photochem. Photobiol. Sci., 2017, 16, 1441
    DOI: 10.1039/C7PP00163K

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