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Issue 2, 2017
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meso-Acetoxymethyl BODIPY dyes for photodynamic therapy: improved photostability of singlet oxygen photosensitizers

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Abstract

We report two BODIPY based photosensitizers (Br2BOAc and I2BOAc) featuring an acetoxymethyl substituent at the meso-position. These photosensitizers show improved photostability against singlet oxygen, when compared to a BODIPY photosensitizer lacking the acetoxymethyl group. Both compounds were evaluated for photodynamic therapy against HeLa cells and photodynamic inactivation against E. coli bacteria. We show that the compounds readily embed in the lipid membranes of HeLa cervical cancer cells and efficiently induced light-dependent apoptosis at nanomolar concentration. Also, both compounds showed a substantial degree of photoinactivation of E. coli bacteria when used at low micromolar concentrations.

Graphical abstract: meso-Acetoxymethyl BODIPY dyes for photodynamic therapy: improved photostability of singlet oxygen photosensitizers

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Publication details

The article was received on 25 May 2016, accepted on 08 Dec 2016 and first published on 08 Dec 2016


Article type: Paper
DOI: 10.1039/C6PP00166A
Citation: Photochem. Photobiol. Sci., 2017,16, 178-184
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    meso-Acetoxymethyl BODIPY dyes for photodynamic therapy: improved photostability of singlet oxygen photosensitizers

    R. Lincoln, A. M. Durantini, L. E. Greene, S. R. Martínez, R. Knox, M. C. Becerra and G. Cosa, Photochem. Photobiol. Sci., 2017, 16, 178
    DOI: 10.1039/C6PP00166A

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