Jump to main content
Jump to site search

Issue 35, 2017
Previous Article Next Article

Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea

Author affiliations

Abstract

The volatiles emitted by five fungal strains previously isolated from the marine sponge Callyspongia cf. flammea were captured with a closed-loop stripping apparatus (CLSA) and analyzed by GC-MS. Besides several widespread compounds, a series of metabolites with interesting bioactivities were found, including the quorum sensing inhibitor protoanemonin, the fungal phytotoxin 3,4-dimethylpentan-4-olide, and the insect attractant 1,2,4-trimethoxybenzene. In addition, the aromatic polyketides isotorquatone and chartabomone that are both known from Eucalyptus and a new O-desmethyl derivative were identified. The biosynthesis of isotorquatone was studied by feeding experiments with isotopically labeled precursors and its absolute configuration was determined by enantioselective synthesis of a reference compound. Bioactivity testings showed algicidal activity for some of the identified compounds, suggesting a potential ecological function in sponge defence.

Graphical abstract: Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Jul 2017, accepted on 30 Aug 2017 and first published on 05 Sep 2017


Article type: Paper
DOI: 10.1039/C7OB01837A
Citation: Org. Biomol. Chem., 2017,15, 7411-7421
  •   Request permissions

    Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea

    L. Barra, P. Barac, G. M. König, M. Crüsemann and J. S. Dickschat, Org. Biomol. Chem., 2017, 15, 7411
    DOI: 10.1039/C7OB01837A

Search articles by author

Spotlight

Advertisements