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A study of synthetic approaches to 2-acyl DHA lysophosphatidic acid

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Abstract

Lysophosphatidic acid (LPA) is a chemical mediator with a very simple glycerophospholipid structure. 1-Acyl LPA and 2-acyl LPA are biosynthesized in vivo. Unlike 1-acyl LPA, the biological function of 2-acyl LPA has been hardly elucidated and even organic synthesis of 2-acyl LPA had not been established. We suppressed acyl migration by formation of a salt with a phosphate group in order to synthesize 2-acyl LPA condensed with docosahexaenoic acid.

Graphical abstract: A study of synthetic approaches to 2-acyl DHA lysophosphatidic acid

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Publication details

The article was received on 19 Jul 2017, accepted on 12 Sep 2017 and first published on 12 Sep 2017


Article type: Paper
DOI: 10.1039/C7OB01771E
Citation: Org. Biomol. Chem., 2017, Advance Article
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    A study of synthetic approaches to 2-acyl DHA lysophosphatidic acid

    Y. Yamamoto, T. Itoh and K. Yamamoto, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01771E

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