Issue 21, 2017

Organocatalytic synthesis of axially chiral atropisomers

Abstract

This Review summarises the recent progress made in the organocatalytic synthesis of atropisomeric compounds. Methodologies based on dynamic kinetic resolution and direct access to BINOL-like biaryls are described. A particular emphasis is given to reaction mechanisms and to the development of strategies to obtain stable products by increasing the barrier to atropisomer interconversion during the reaction.

Graphical abstract: Organocatalytic synthesis of axially chiral atropisomers

Article information

Article type
Review Article
Submitted
12 Apr 2017
Accepted
03 May 2017
First published
03 May 2017

Org. Biomol. Chem., 2017,15, 4506-4516

Organocatalytic synthesis of axially chiral atropisomers

P. Renzi, Org. Biomol. Chem., 2017, 15, 4506 DOI: 10.1039/C7OB00908A

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