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Issue 15, 2017
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Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery

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Abstract

An unnatural CDP-amino acid (kd) is used in the design and synthesis of novel cell penetrating peptidomimetic (Kkd-5). The balanced cationic nature and structural rigidity of Kkd-5 resulted in serum stability, non-toxicity to cells, and interaction with membrane and DNA, all of which facilitated efficient cellular uptake and DNA delivery.

Graphical abstract: Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery

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Publication details

The article was received on 21 Jan 2017, accepted on 20 Mar 2017 and first published on 21 Mar 2017


Article type: Communication
DOI: 10.1039/C7OB00167C
Citation: Org. Biomol. Chem., 2017,15, 3170-3174
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    Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery

    C. Madhu, C. Voshavar, K. Rajasekhar and T. Govindaraju, Org. Biomol. Chem., 2017, 15, 3170
    DOI: 10.1039/C7OB00167C

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