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Issue 11, 2017
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Diversity-oriented synthesis and cytotoxic activity evaluation of biaryl-containing macrocycles

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Abstract

Synthesis of biaryl-containing macrocycles has been carried out through a four-step approach comprising two Ugi four component reactions and a Suzuki–Miyaura macrocyclization. This protocol allowed the synthesis of 12- and 14-membered macrocycles. Cytotoxic activity evaluation showed that some of the molecules were effective against leukemia, glioblastoma and lung cancer cell lines (IC50 = 4.0, 5.9 and 7.6, respectively).

Graphical abstract: Diversity-oriented synthesis and cytotoxic activity evaluation of biaryl-containing macrocycles

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Publication details

The article was received on 14 Dec 2016, accepted on 23 Feb 2017 and first published on 23 Feb 2017


Article type: Paper
DOI: 10.1039/C6OB02726A
Citation: Org. Biomol. Chem., 2017,15, 2450-2458
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    Diversity-oriented synthesis and cytotoxic activity evaluation of biaryl-containing macrocycles

    K. Pérez-Labrada, M. A. Cruz-Mendoza, A. Chávez-Riveros, E. Hernández-Vázquez, T. Torroba and L. D. Miranda, Org. Biomol. Chem., 2017, 15, 2450
    DOI: 10.1039/C6OB02726A

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