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Issue 5, 2017
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Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

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Abstract

Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation.

Graphical abstract: Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

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Publication details

The article was received on 30 Nov 2016, accepted on 03 Jan 2017 and first published on 04 Jan 2017


Article type: Communication
DOI: 10.1039/C6OB02616H
Citation: Org. Biomol. Chem., 2017,15, 1100-1105
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    Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

    T. Hanauer, R. J. Hopkinson, K. Patel, Y. Li, D. Correddu, A. Kawamura, V. Sarojini, I. K. H. Leung and T. Gruber, Org. Biomol. Chem., 2017, 15, 1100
    DOI: 10.1039/C6OB02616H

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