Issue 7, 2017
From the journal:

Organic & Biomolecular Chemistry

Synthesis of aminopyrazoles from sydnones and ynamides†

T. Wezeman, ORCID logo a   J. Comas-Barceló,b   M. Nieger,c   J. P. A. Harrityb  and  S. Bräse*ad  

* Corresponding authors

a Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany
E-mail: braese@kit.edu

b Department of Chemistry, The University of Sheffield, Brook Hill, Sheffield, UK
E-mail: j.harrity@sheffield.ac.uk

c Department of Chemistry, University of Helsinki, Finland

d Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

Abstract

Aminopyrazoles are prepared from readily accessible sydnones and sulfonyl ynamides using either a copper-mediated sydnone alkyne cycloaddition (CuSAC) or in situ generated strained cyclic ynamides.

Graphical abstract: Synthesis of aminopyrazoles from sydnones and ynamides

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Article information

DOI
https://doi.org/10.1039/C6OB02518H
Article type
Communication
Submitted
17 Nov 2016
Accepted
16 Jan 2017
First published
25 Jan 2017

Org. Biomol. Chem., 2017,15, 1575-1579

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Synthesis of aminopyrazoles from sydnones and ynamides

T. Wezeman, J. Comas-Barceló, M. Nieger, J. P. A. Harrity and S. Bräse, Org. Biomol. Chem., 2017, 15, 1575 DOI: 10.1039/C6OB02518H

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