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Issue 1, 2017
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Pd-mediated cross-coupling of C-17 lithiated androst-16-en-3-ol – access to functionalized arylated steroid derivatives

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Abstract

Herein, we report on Pd-mediated cross-coupling of vinyllithium steroids and aryl bromides to introduce various substituted aryls at C-17 of steroidal frameworks based on the structure of epi-androsterone. Compared to other C–C cross-couplings, this method turned out to be an easy and competitive access to biologically interesting C-17 modified steroids.

Graphical abstract: Pd-mediated cross-coupling of C-17 lithiated androst-16-en-3-ol – access to functionalized arylated steroid derivatives

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Publication details

The article was received on 15 Nov 2016, accepted on 22 Nov 2016 and first published on 22 Nov 2016


Article type: Communication
DOI: 10.1039/C6OB02496C
Citation: Org. Biomol. Chem., 2017,15, 92-95
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    Pd-mediated cross-coupling of C-17 lithiated androst-16-en-3-ol – access to functionalized arylated steroid derivatives

    V. Koch and S. Bräse, Org. Biomol. Chem., 2017, 15, 92
    DOI: 10.1039/C6OB02496C

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