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Issue 5, 2017
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Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation

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Abstract

Green fluorescent protein (GFP)-based molecular-rotor chromophores were attached to the 5-positions of deoxyuridines, and subsequently, incorporated into the middle positions of oligodeoxynucleotides. These oligonucleotides were designed to form triplex DNA in order to encapsulate the GFP chromophores, mimicking GFP structures. Upon triplex formation, the embedded GFP chromophores exhibited fluorescence enhancement, suggesting the potential application of these fluorescent probes for the detection of nucleic acids.

Graphical abstract: Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation

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Publication details

The article was received on 14 Jun 2016, accepted on 23 Dec 2016 and first published on 13 Jan 2017


Article type: Paper
DOI: 10.1039/C6OB01278G
Citation: Org. Biomol. Chem., 2017,15, 1190-1197
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    Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation

    T. Kanamori, A. Takamura, N. Tago, Y. Masaki, A. Ohkubo, M. Sekine and K. Seio, Org. Biomol. Chem., 2017, 15, 1190
    DOI: 10.1039/C6OB01278G

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