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Issue 24, 2017
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Microemulsion-made gadolinium carbonate hollow nanospheres showing magnetothermal heating and drug release

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Abstract

Gadolinium carbonate (Gd2(CO3)3) hollow nanospheres and their suitability for drug transport and magnetothermally-induced drug release are presented. The hollow nanospheres are prepared via a microemulsion-based synthesis using tris(tetramethylcyclopentadienyl)gadolinium(III) and CO2 as the starting materials. Size, structure and composition of the as-prepared Gd2(CO3)3 hollow nanospheres are comprehensively validated by several independent analytical methods (HRTEM, HAADF-STEM, DLS, EDXS, XRD, FT-IR, DTA-TG). Accordingly, they exhibit an outer diameter of 26 ± 4 nm, an inner cavity of 7 ± 2 nm, and a wall thickness of 9 ± 3 nm. As a conceptual study, the nanocontainer-functionality of the Gd2(CO3)3 hollow nanospheres is validated upon filling with the anti-cancerogenic agent doxorubicin (DOX), which is straightforward via the microemulsion (ME) strategy. The resulting DOX@Gd2(CO3)3 nanocontainers provide the option of multimodal imaging including optical and magnetic resonance imaging (OI, MRI) as well as magnetothermal heating and drug release. As a proof-of-concept, we could already prove the intrinsic DOX-based fluorescence, a low systemic toxicity according to in vitro studies as well as the magnetothermal effect and a magnetothermally-induced DOX release. In particular, the latter is new for Gd-containing nanoparticles and highly promising in view of theranostic nanocontainers and synergistic physical and chemical tumor treatment.

Graphical abstract: Microemulsion-made gadolinium carbonate hollow nanospheres showing magnetothermal heating and drug release

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Publication details

The article was received on 13 Mar 2017, accepted on 20 May 2017 and first published on 23 May 2017


Article type: Paper
DOI: 10.1039/C7NR01784G
Citation: Nanoscale, 2017,9, 8362-8372
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    Microemulsion-made gadolinium carbonate hollow nanospheres showing magnetothermal heating and drug release

    J. Jung-König, M. Sanhaji, R. Popescu, C. Seidl, E. Zittel, U. Schepers, D. Gerthsen, I. Hilger and C. Feldmann, Nanoscale, 2017, 9, 8362
    DOI: 10.1039/C7NR01784G

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