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Issue 27, 2017
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Janus plasmonic–magnetic gold–iron oxide nanoparticles as contrast agents for multimodal imaging

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Abstract

The design of compact nanoprobes for multimodal bioimaging is a current challenge and may have a major impact on diagnostics and therapeutics. Multicomponent gold–iron oxide nanoparticles have shown high potential as contrast agents in numerous imaging techniques due to the complementary features of iron oxide and gold nanomaterials. In this paper we describe novel gold–iron oxide Janus magnetic–plasmonic nanoparticles as versatile nanoprobes for multimodal imaging. The nanoparticles are characterized as contrast agents for different imaging techniques, including X-ray computed tomography (CT), T2-weighted nuclear magnetic resonance imaging (MRI), photoacoustic imaging (PA), dark-field and bright-field optical microscopy, transmission electron microscopy (TEM), and surface enhanced Raman spectroscopy (SERS). We discuss the effect of particle size and morphology on their performance as contrast agents and show the advantage of a Janus configuration. Additionally, the uptake of nanoparticles by cells can be simultaneously visualized in dark- and bright-field optical microscopy, SERS mapping, and electron microscopy. These complementary techniques allow a complete view of cell uptake in an artifact-free manner, with multiplexing capabilities, and with extra information regarding the nanoparticles’ fate inside the cells. Altogether, the results obtained with these non-invasive techniques show the high versatility of these nanoparticles, the advantages of a Janus configuration, and their high potential in multipurpose biomedical applications.

Graphical abstract: Janus plasmonic–magnetic gold–iron oxide nanoparticles as contrast agents for multimodal imaging

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Publication details

The article was received on 25 Feb 2017, accepted on 20 Jun 2017 and first published on 22 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR01406F
Citation: Nanoscale, 2017,9, 9467-9480
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    Janus plasmonic–magnetic gold–iron oxide nanoparticles as contrast agents for multimodal imaging

    J. Reguera, D. Jiménez de Aberasturi, M. Henriksen-Lacey, J. Langer, A. Espinosa, B. Szczupak, C. Wilhelm and L. M. Liz-Marzán, Nanoscale, 2017, 9, 9467
    DOI: 10.1039/C7NR01406F

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