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Issue 2, 2017
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Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain

Asahi Tomitaka,a  Hamed Arami,bc  Andrea Raymond,a  Adriana Yndart,a  Ajeet Kaushik,a  Rahul Dev Jayant,a  Yasushi Takemura,d  Yong Cai,e  Michal Toborekf  and  Madhavan Nair*ag 
Author affiliations

* Corresponding authors

a Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, USA
E-mail: nairm@fiu.edu

b Molecular Imaging Program at Stanford (MIPS), The James H Clark Center, Stanford University, Stanford, USA

c Department of Radiology, Stanford University School of Medicine, Stanford, USA

d Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan

e Department of Chemistry & Biochemistry, Southeast Environmental Research Center, Florida International University, Miami, USA

f Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, USA

g Department of Immunology, Institute of NeuroImmune Pharmacology, Centre for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, USA

Abstract

Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core/gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ions on magnetic nanoparticle seeds. Hydrodynamic size and optical properties of magneto-plasmonic nanoparticles synthesized with the variation of Au ions and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic properties, and their magnetic properties contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of the magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of the magneto-plasmonic nanoparticles using an in vitro blood–brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting the integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.

Graphical abstract: Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain

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Publication details

The article was received on 23 Sep 2016, accepted on 10 Nov 2016 and first published on 11 Nov 2016


Article type: Paper
DOI: 10.1039/C6NR07520G
Citation: Nanoscale, 2017,9, 764-773
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    Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain

    A. Tomitaka, H. Arami, A. Raymond, A. Yndart, A. Kaushik, R. D. Jayant, Y. Takemura, Y. Cai, M. Toborek and M. Nair, Nanoscale, 2017, 9, 764
    DOI: 10.1039/C6NR07520G

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