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Issue 1, 2017
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Rapid detection of Hendra virus antibodies: an integrated device with nanoparticle assay and chaotic micromixing

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Abstract

Current diagnosis of infectious diseases such as Hendra virus (HeV) relies mostly on laboratory-based tests. There is an urgent demand for rapid diagnosis technology to detect and identify these diseases in humans and animals so that disease spread can be controlled. In this study, an integrated lab-on-a-chip device using a magnetic nanoparticle immunoassay is developed. The key features of the device are the chaotic fluid mixing, achieved by magnetically driven motion of nanoparticles with the optimal mixing protocol developed using chaotic transport theory, and the automatic liquid handling system for loading reagents and samples. The device has been demonstrated to detect Hendra virus antibodies in dilute horse serum samples within a short time of 15 minutes and the limit of detection is about 0.48 ng ml−1. The device platform can potentially be used for field detection of viruses and other biological and chemical substances.

Graphical abstract: Rapid detection of Hendra virus antibodies: an integrated device with nanoparticle assay and chaotic micromixing

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Publication details

The article was received on 12 Oct 2016, accepted on 20 Nov 2016 and first published on 24 Nov 2016


Article type: Paper
DOI: 10.1039/C6LC01263A
Citation: Lab Chip, 2017,17, 169-177
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    Rapid detection of Hendra virus antibodies: an integrated device with nanoparticle assay and chaotic micromixing

    K. Petkovic, G. Metcalfe, H. Chen, Y. Gao, M. Best, D. Lester and Y. Zhu, Lab Chip, 2017, 17, 169
    DOI: 10.1039/C6LC01263A

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