Issue 6, 2017

A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU

Abstract

Diazomethane is a valuable C1-building block for organic synthesis. Due to its intrinsic reactivity and instability, handling of this reagent is associated with serious safety hazards. Herein we present a simple and robust continuous flow process, allowing a safe and on-demand generation of diazomethane with a productivity of 95–117 mmol h−1. The developed two-step process starts from non-hazardous N-methylurea, and generates and consumes N-methyl-N-nitrosourea (MNU) and diazomethane, thus enabling a safe and convenient scale-up to a multi-gram scale in a conventional synthesis laboratory.

Graphical abstract: A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU

Supplementary files

Article information

Article type
Paper
Submitted
07 Nov 2016
Accepted
09 Dec 2016
First published
09 Dec 2016

Green Chem., 2017,19, 1449-1453

A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU

H. Lehmann, Green Chem., 2017, 19, 1449 DOI: 10.1039/C6GC03066A

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