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Issue 18, 2017
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Metal-free oxidative cyclization of 2-aminobenzothiazoles and cyclic ketones enabled by the combination of elemental sulfur and oxygen

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Abstract

Metal-free oxidative cyclization for the one-pot synthesis of benzo[d]imidazo[2,1-b]thiazoles from 2-aminobenzothiazoles and cyclic ketones is described. Elemental sulfur combined with molecular oxygen as the benign co-oxidant was found to be unique and highly effective to promote this transformation without the aid of any metal salts. Various cyclic ketones smoothly reacted with 2-aminobenzothiazoles to give functional benzo[d]imidazo[2,1-b]thiazoles in good to very high yields, which thereby demonstrated the synthetic convergence of this methodology.

Graphical abstract: Metal-free oxidative cyclization of 2-aminobenzothiazoles and cyclic ketones enabled by the combination of elemental sulfur and oxygen

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Publication details

The article was received on 04 Jul 2017, accepted on 16 Aug 2017 and first published on 16 Aug 2017


Article type: Communication
DOI: 10.1039/C7GC02014G
Citation: Green Chem., 2017,19, 4294-4298
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    Metal-free oxidative cyclization of 2-aminobenzothiazoles and cyclic ketones enabled by the combination of elemental sulfur and oxygen

    Y. Xie, X. Chen, Z. Wang, H. Huang, B. Yi and G. Deng, Green Chem., 2017, 19, 4294
    DOI: 10.1039/C7GC02014G

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