Jump to main content
Jump to site search


An Environment-Friendly Protocol for Oxidative Halocyclization of Tryptamine and Tryptophol Derivatives

Abstract

An environmentally friendlyand efficient protocol (KX/oxone) for oxidative halocyclization of tryptamine/tryptophol derivatives was developed and demonstrated with 28 examples and concise total synthesis of cyclotryptamine alkaloid protubonines A and B. The distinct advantage of this protocol over all previous methods was no organic byproduct arisen from halogenating agent or oxidant, thus greatly reducing the environment impact of halocyclization and facilitating the post-reaction purification.

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 05 May 2017, accepted on 18 May 2017 and first published on 18 May 2017


Article type: Communication
DOI: 10.1039/C7GC01341H
Citation: Green Chem., 2017, Accepted Manuscript
  •   Request permissions

    An Environment-Friendly Protocol for Oxidative Halocyclization of Tryptamine and Tryptophol Derivatives

    J. Xu and R. Tong, Green Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7GC01341H

Search articles by author