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Issue 13, 2017
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Synthesis of 2-substituted quinazolines by CsOH-mediated direct aerobic oxidative cyclocondensation of 2-aminoarylmethanols with nitriles in air

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Abstract

By using air as the superior oxidant, a highly atom-efficient synthesis of 2-substituted quinazolines is developed by a CsOH-mediated direct aerobic oxidative reaction of the readily available and stable 2-aminoarylmethanols and nitriles. Effectively working as the promoter in the alcohol oxidation, nitrile hydration, and cyclocondensation steps, CsOH is the best base for the reaction. A similar method can also be extended to the synthesis of substituted quinolines starting from methyl ketones instead of nitriles.

Graphical abstract: Synthesis of 2-substituted quinazolines by CsOH-mediated direct aerobic oxidative cyclocondensation of 2-aminoarylmethanols with nitriles in air

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Publication details

The article was received on 30 Mar 2017, accepted on 12 May 2017 and first published on 15 May 2017


Article type: Communication
DOI: 10.1039/C7GC00977A
Citation: Green Chem., 2017,19, 2945-2951
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    Synthesis of 2-substituted quinazolines by CsOH-mediated direct aerobic oxidative cyclocondensation of 2-aminoarylmethanols with nitriles in air

    S. Yao, K. Zhou, J. Wang, H. Cao, L. Yu, J. Wu, P. Qiu and Q. Xu, Green Chem., 2017, 19, 2945
    DOI: 10.1039/C7GC00977A

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