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Issue 5, 2017
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Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

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Abstract

An efficient and green procedure for the synthesis of tetrazines has been developed based on an old chemistry reported by Carboni in 1958. Both symmetric and asymmetric 3,6-disubstituted 1,2,4,5-tetrazines can be obtained in moderate to high yields from the corresponding gem-difluoroalkenes under aerobic conditions at room temperature. This work represents a rare example that ambient air is utilized as an oxidant for the synthesis of tetrazines.

Graphical abstract: Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

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Publication details

The article was received on 19 Dec 2016, accepted on 17 Jan 2017 and first published on 18 Jan 2017


Article type: Paper
DOI: 10.1039/C6GC03494B
Citation: Green Chem., 2017,19, 1299-1302
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    Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

    Z. Fang, W. Hu, D. Liu, C. Yu and X. Hu, Green Chem., 2017, 19, 1299
    DOI: 10.1039/C6GC03494B

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