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Issue 4, 2017
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Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

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Abstract

A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.

Graphical abstract: Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

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Publication details

The article was received on 06 Dec 2016, accepted on 01 Jan 2017 and first published on 02 Jan 2017


Article type: Communication
DOI: 10.1039/C6GC03355E
Citation: Green Chem., 2017,19, 919-923
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    Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

    P. Zhang, J. Li, L. Zhang, A. Shoberu, J. Zou and W. Zhang, Green Chem., 2017, 19, 919
    DOI: 10.1039/C6GC03355E

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