Jump to main content
Jump to site search

Issue 4, 2017
Previous Article Next Article

Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Author affiliations

Abstract

A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.

Graphical abstract: Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 06 Dec 2016, accepted on 01 Jan 2017, published on 02 Jan 2017 and first published online on 02 Jan 2017


Article type: Communication
DOI: 10.1039/C6GC03355E
Citation: Green Chem., 2017,19, 919-923
  •   Request permissions

    Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

    P. Zhang, J. Li, L. Zhang, A. Shoberu, J. Zou and W. Zhang, Green Chem., 2017, 19, 919
    DOI: 10.1039/C6GC03355E

Search articles by author