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Issue 3, 2017
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Efficient atom and step economic (EASE) synthesis of the “smart drug” Modafinil

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Abstract

Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide, MOD) is a key psychostimulant drug used for the treatment of narcolepsy and other sleep disorders that has a very low addiction liability. Recently, MOD has been clinically investigated for the treatment of cocaine addiction and used by astronauts in long-term space missions. We have developed a synthetic strategy for “smart drug” Modafinil. An efficient atom and step economic (EASE) synthesis has been carried out by the direct reaction of benzhydrol and 2-mercaptoacetamide using the recyclable heterogeneous catalyst Nafion-H along with post-sulfoxidation. This protocol exhibits improved sustainability credentials. We have also developed a superior pre-sulfoxidation approach for the synthesis of Modafinil.

Graphical abstract: Efficient atom and step economic (EASE) synthesis of the “smart drug” Modafinil

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Publication details

The article was received on 19 Sep 2016, accepted on 30 Nov 2016 and first published on 30 Nov 2016


Article type: Communication
DOI: 10.1039/C6GC02623K
Citation: Green Chem., 2017,19, 629-633
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    Efficient atom and step economic (EASE) synthesis of the “smart drug” Modafinil

    S. Maurya, D. Yadav, K. Pratap and A. Kumar, Green Chem., 2017, 19, 629
    DOI: 10.1039/C6GC02623K

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