Jump to main content
Jump to site search

Issue 10, 2017
Previous Article Next Article

Cytotoxic gold(III) complexes incorporating a 2,2′:6′,2′′-terpyridine ligand framework – the impact of the substituent in the 4′-position of a terpy ring

Author affiliations

Abstract

Two gold(III) complexes incorporating 2,2′:6′,2′′-terpyridine derivatives have been synthesised and characterized, and the possibility of tuning the cytotoxic activity by structural modifications of a terpy ligand has been examined. Both complexes [AuCl(4′-R1-terpy)](PF6)2 (1) and [AuCl(4′-R2-terpy)](PF6)2 (2), where R1 is 2-pyridyl and R2 is 3-pyridyl, show good anti-proliferative activities against HCT116, which are higher in relation to those of the free ligands, [AuCl(terpy)](PF6)2 and standard anticancer drug cisplatin. The cytotoxic properties of the gold complexes were examined by MTS assay, cell cycle and apoptosis analysis, ROS measurements, determination of mitochondrial membrane potential and mass, and staining of phosphatidylserine with Annexin-V antibody FITC-conjugated together with PI.

Graphical abstract: Cytotoxic gold(iii) complexes incorporating a 2,2′:6′,2′′-terpyridine ligand framework – the impact of the substituent in the 4′-position of a terpy ring

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Dec 2016, accepted on 15 Feb 2017 and first published on 16 Feb 2017


Article type: Paper
DOI: 10.1039/C6DT04584G
Citation: Dalton Trans., 2017,46, 3381-3392
  •   Request permissions

    Cytotoxic gold(III) complexes incorporating a 2,2′:6′,2′′-terpyridine ligand framework – the impact of the substituent in the 4′-position of a terpy ring

    K. Czerwińska, M. Golec, M. Skonieczna, J. Palion-Gazda, D. Zygadło, A. Szlapa-Kula, S. Krompiec, B. Machura and A. Szurko, Dalton Trans., 2017, 46, 3381
    DOI: 10.1039/C6DT04584G

Search articles by author

Spotlight

Advertisements