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Issue 2, 2017
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Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

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Abstract

Supramolecular Pt(II) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.

Graphical abstract: Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

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Publication details

The article was received on 07 Oct 2016, accepted on 23 Nov 2016 and first published on 23 Nov 2016


Article type: Communication
DOI: 10.1039/C6DT03876J
Citation: Dalton Trans., 2017,46, 329-332
  • Open access: Creative Commons BY-NC license
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    Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

    O. Domarco, D. Lötsch, J. Schreiber, C. Dinhof, S. Van Schoonhoven, M. D. García, C. Peinador, B. K. Keppler, W. Berger and A. Terenzi, Dalton Trans., 2017, 46, 329
    DOI: 10.1039/C6DT03876J

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