Jump to main content
Jump to site search

Issue 9, 2017
Previous Article Next Article

Surveying macrocyclic chemistry: from flexible crown ethers to rigid cyclophanes

Author affiliations

Abstract

Macrocycles are molecular entities that display a combination of molecular recognition and complexation properties with vital implications for host–guest/supramolecular chemistry. Since the accidental discovery of the crown ethers by Pedersen half a century ago, the chemistry of wholly synthetic macrocycles for structure-specific, highly selective, host–guest complexation has experienced rapid development. While the structural diversity and host–guest chemistry of the original macrocycles are well-known, new derivatives of them are being investigated continuously and reported on today in order to improve their recognition properties as well as to unleash new opportunities in supramolecular chemistry. In this Review, we survey the recent developments of the chemistry of naturally occurring cyclodextrins, along with a variety of synthetic flexible and rigid macrocycles that have drawn their inspiration from Pedersen's ground-breaking discovery of crown ethers in the mid-1960s.

Graphical abstract: Surveying macrocyclic chemistry: from flexible crown ethers to rigid cyclophanes

Back to tab navigation

Publication details

The article was received on 11 Mar 2017 and first published on 02 May 2017


Article type: Review Article
DOI: 10.1039/C7CS00185A
Citation: Chem. Soc. Rev., 2017,46, 2459-2478
  •   Request permissions

    Surveying macrocyclic chemistry: from flexible crown ethers to rigid cyclophanes

    Z. Liu, S. K. M. Nalluri and J. F. Stoddart, Chem. Soc. Rev., 2017, 46, 2459
    DOI: 10.1039/C7CS00185A

Search articles by author

Spotlight

Advertisements