Jump to main content
Jump to site search

Issue 9, 2017
Previous Article Next Article

Charles J. Pedersen's legacy to chemistry

Author affiliations


The serendipitous discovery in 1961 of dibenzo-18-crown-6 by Charles J. Pedersen marked the beginning of research on cyclic polyether macrocyclic compounds. These compounds have a remarkably selective affinity for certain metal ions and provide a framework for studying molecular recognition processes. Pedersen's work excited much interest in the scientific community and fueled important advances in macrocyclic and supramolecular chemistry. Born in Korea of a Japanese mother and a Norwegian engineer father, he was educated in Japan and later graduated from the University of Dayton (BS, chemical engineering) and Massachusetts Institute of Technology (MS, chemistry). He worked at du Pont for 42 years as a research chemist. His research talent at du Pont earned him an appointment as a Research Associate allowing him to pursue research as he chose. This freedom served him well making it possible for him to devote all his efforts following his discovery of dibenzo-18-crown-6 until his retirement to synthesis of cyclic polyethers and evaluation of their metal ion complexation properties. His influence on macrocyclic and supramolecular chemistry has been pervasive. He was co-recipient of the 1987 Nobel Prize in chemistry for development and use of molecules with structure-specific interactions of high selectivity. The year 2017 marks the fiftieth anniversary of the publication of his first paper describing his synthesis of over 50 crown ethers.

Graphical abstract: Charles J. Pedersen's legacy to chemistry

Back to tab navigation

Publication details

The article was received on 17 Feb 2017 and first published on 11 Apr 2017

Article type: Highlight
DOI: 10.1039/C7CS00128B
Citation: Chem. Soc. Rev., 2017,46, 2380-2384
  •   Request permissions

    Charles J. Pedersen's legacy to chemistry

    R. M. Izatt, Chem. Soc. Rev., 2017, 46, 2380
    DOI: 10.1039/C7CS00128B

Search articles by author