Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate

Jiawang Wang; Jianhong Zhao; Hegui Gong

doi:10.1039/C7CC06106D

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Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate†

Jiawang Wang,

^a Jianhong Zhao*^b and Hegui Gong

*^a

Author affiliations

* Corresponding authors

^a Center for Supramolecular Chemistry and Catalysis and Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China
E-mail: hegui_gong@shu.edu.cn

^b Laboratory of Green Pharmaceutical Process & Technology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
E-mail: zjhpharm@163.com

Abstract

This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with methyl tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes.

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Article information

DOI: https://doi.org/10.1039/C7CC06106D
Article type: Communication
Submitted: 04 Aug 2017
Accepted: 23 Aug 2017
First published: 23 Aug 2017

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Chem. Commun., 2017,53, 10180-10183

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Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate

J. Wang, J. Zhao and H. Gong, Chem. Commun., 2017, 53, 10180 DOI: 10.1039/C7CC06106D

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Chemical Communications

Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate†

Abstract

Supplementary files

Article information

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Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate

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