Issue 81, 2017

Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

Abstract

A naphthalimide-based chemosensing motif turns ON the fluorescence emission in solution in the presence of aqueous iron(III) chloride, and maintains this property in living cancer cells. The emission response to Fe(III) ions occurs simultaneously with a change in pH. The protonation of methyl piperazine-conjugated naphthalimide promotes its lysosomal localisation as assessed by co-localisation tests and fluorescence lifetime imaging microscopy (FLIM) in vitro.

Graphical abstract: Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

Supplementary files

Article information

Article type
Communication
Submitted
04 Jul 2017
Accepted
01 Sep 2017
First published
01 Sep 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 11161-11164

Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

M. Li, H. Ge, V. Mirabello, R. L. Arrowsmith, G. Kociok-Köhn, S. W. Botchway, W. Zhu, S. I. Pascu and T. D. James, Chem. Commun., 2017, 53, 11161 DOI: 10.1039/C7CC05166B

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