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Issue 57, 2017
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DNA or protein? Capillary zone electrophoresis–mass spectrometry rapidly elucidates metallodrug binding selectivity

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Abstract

A novel capillary zone electrophoresis–mass spectrometry (CZE–MS) approach allows the simultaneous characterization and quantification of the binding of metal-based anticancer agents to biomolecules. Moreover, for the first time, oligonucleotide metallation was resolved at single-nucleotide resolution by MS.

Graphical abstract: DNA or protein? Capillary zone electrophoresis–mass spectrometry rapidly elucidates metallodrug binding selectivity

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Publication details

The article was received on 13 Jun 2017, accepted on 25 Jun 2017 and first published on 27 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC04582D
Citation: Chem. Commun., 2017,53, 8002-8005
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    DNA or protein? Capillary zone electrophoresis–mass spectrometry rapidly elucidates metallodrug binding selectivity

    C. Artner, H. U. Holtkamp, W. Kandioller, C. G. Hartinger, S. M. Meier-Menches and B. K. Keppler, Chem. Commun., 2017, 53, 8002
    DOI: 10.1039/C7CC04582D

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