Jump to main content
Jump to site search

Issue 62, 2017
Previous Article Next Article

Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

Author affiliations

Abstract

Biodegradable polymers have emerged as highly effective drug delivery vehicles. We combine N-carboxyanhydride and O-carboxyanhydride ring opening polymerisations to synthesise a poly(amino acid)-polyester graft copolymer capable of encapsulating, and subsequently releasing doxorubicin via acid-mediated hydrolysis. Consequently, the nanoparticles detailed are extremely promising vehicles for the controlled delivery of chemotherapeutic agents.

Graphical abstract: Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Jun 2017, accepted on 13 Jul 2017 and first published on 13 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04504B
Citation: Chem. Commun., 2017,53, 8687-8690
  •   Request permissions

    Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

    D. J. Price, M. Khuphe, R. P. W. Davies, J. R. McLaughlan, N. Ingram and P. D. Thornton, Chem. Commun., 2017, 53, 8687
    DOI: 10.1039/C7CC04504B

Search articles by author

Spotlight

Advertisements