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Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

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Abstract

Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-peptide might be important for the endogenous inhibition of IAPP aggregation.

Graphical abstract: Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

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Publication details

The article was received on 02 Jun 2017, accepted on 19 Jul 2017 and first published on 19 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC04291D
Citation: Chem. Commun., 2017, Advance Article
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    Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

    X. Ge, A. Kakinen, E. N. Gurzov, W. Yang, L. Pang, E. H. Pilkington, P. Govindan-Nedumpully, P. Chen, F. Separovic, T. P. Davis, P. C. Ke and F. Ding, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC04291D

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