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Issue 54, 2017
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Pd(0)-Catalyzed intramolecular arylative dearomatization of β-naphthols

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Abstract

An efficient Pd(0)-catalyzed intramolecular arylative dearomatization of β-naphthols is described. Using Q-Phos as a ligand, the arylative dearomatization reaction proceeded smoothly affording excellent yields and chemoselectivity even when the catalyst loading was reduced to 0.1 mol%. This method offers an efficient access to a series of structurally diverse spirocarbocycles. Preliminary investigation indicates that an enantioselective reaction is feasible in the presence of a chiral phosphoramidite ligand.

Graphical abstract: Pd(0)-Catalyzed intramolecular arylative dearomatization of β-naphthols

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Publication details

The article was received on 25 May 2017, accepted on 13 Jun 2017 and first published on 13 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC04022A
Citation: Chem. Commun., 2017,53, 7553-7556
  • Open access: Creative Commons BY-NC license
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    Pd(0)-Catalyzed intramolecular arylative dearomatization of β-naphthols

    R. Xu, P. Yang and S. You, Chem. Commun., 2017, 53, 7553
    DOI: 10.1039/C7CC04022A

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