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Issue 49, 2017
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[11C]Cyanation of arylboronic acids in aqueous solutions

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Abstract

A copper-mediated 11C-cyanation method employing arylboronic acids and [11C]HCN has been developed. This method was applied to the radiochemical synthesis of a wide range of aromatic 11C-nitriles in aqueous solutions. The use of readily accessible arylboronic acids as precursors makes this method complementary to the well-established 11C-cyanation methods that utilize aryl halide precursors.

Graphical abstract: [11C]Cyanation of arylboronic acids in aqueous solutions

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Publication details

The article was received on 14 Apr 2017, accepted on 30 May 2017 and first published on 05 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC02886E
Citation: Chem. Commun., 2017,53, 6597-6600
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    [11C]Cyanation of arylboronic acids in aqueous solutions

    L. Ma, M. S. Placzek, J. M. Hooker, N. Vasdev and S. H. Liang, Chem. Commun., 2017, 53, 6597
    DOI: 10.1039/C7CC02886E

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