Issue 46, 2017
From the journal:

Chemical Communications

A deciduous directing group approach for the addition of aryl and vinyl nucleophiles to maleimides†

Kiran R. Bettadapur, ORCID logo a   Veeranjaneyulu Lanke ORCID logo a  and  Kandikere Ramaiah Prabhu ORCID logo *a  

* Corresponding authors

a Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India
E-mail: prabhu@orgchem.iisc.ernet.in

Abstract

A Rh(III)-catalyzed C–H activation followed by conjugate addition to maleimides, using carboxylic acid as a traceless/deciduous directing group, to formally furnish a Csp2–Csp3 bond is presented. For the first time, derivatives of acrylic acid have been shown as surrogates for the unstable and expensive alkenyl boronic acids.

Graphical abstract: A deciduous directing group approach for the addition of aryl and vinyl nucleophiles to maleimides

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Article information

DOI
https://doi.org/10.1039/C7CC02392H
Article type
Communication
Submitted
28 Mar 2017
Accepted
15 May 2017
First published
15 May 2017

Chem. Commun., 2017,53, 6251-6254

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A deciduous directing group approach for the addition of aryl and vinyl nucleophiles to maleimides

K. R. Bettadapur, V. Lanke and K. R. Prabhu, Chem. Commun., 2017, 53, 6251 DOI: 10.1039/C7CC02392H

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