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Issue 23, 2017
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A new and potentially prebiotic α-cytidine derivative

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Abstract

A new α-cytidine derivative was synthesised from the prebiotic reaction of ribose aminooxazoline and dicyanoacetylene. The tetracyclic structure of the product was confirmed by X-ray diffraction and then an alternative 6-step synthetic pathway to the product was found which was suitable for large-scale synthesis.

Graphical abstract: A new and potentially prebiotic α-cytidine derivative

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Publication details

The article was received on 24 Jan 2017, accepted on 15 Feb 2017 and first published on 23 Feb 2017


Article type: Communication
DOI: 10.1039/C7CC00693D
Citation: Chem. Commun., 2017,53, 3327-3329
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    A new and potentially prebiotic α-cytidine derivative

    M. Tsanakopoulou, J. Xu, A. D. Bond and J. D. Sutherland, Chem. Commun., 2017, 53, 3327
    DOI: 10.1039/C7CC00693D

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